Medical Education

January 2012 View as a webpage | Forward to a colleague | Not subscribed? Subscribe here
Advances in Transplantation
Featured Articles

HLA match is only donor characteristic affecting HCT outcomes

This study of donor characteristics on the outcomes of 709 unrelated donor transplants has found that while donor-recipient HLA match has a significant influence on outcomes, donor age, parity (previous donor pregnancy), and donor sex match did not. The study examined transplant outcomes of reduced-intensity transplants from 1999-2006 in the United States facilitated by the NMDP. Multivariate analysis found that a 1- or 2-HLA mismatch was significantly associated with higher grade II-IV acute GVHD (relative risk [RR]=1.27, p=0.035) and grade III-IV acute GVHD (RR=1.85, p<0.001). Two-loci HLA mismatches were also associated with higher mortality (RR=2.22, p<0.001).

Passweg JR, et al. Biol Blood Marrow Transplant »

Nonmalignant late complications in HCT

This large-scale retrospective study determined the cumulative incidence of late effects following hematopoietic cell transplantation (HCT) performed at Fred Hutchinson Cancer Research Center between 2004-2009. From annual surveys and medical records of 1087 recipients, researchers determined the incidence of 14 different nonmalignant conditions such as osteoporosis, diabetes mellitus, or coronary artery disease. The 5-year cumulative incidence of at least one nonmalignant complication was 44.8% in autologous recipients and 79% in allogeneic recipients. Three or more late effects were reported by 2.5% of autologous recipients and 25.5% of allogeneic recipients.

Khera N, et al. J Clin Oncol »

Patient race/ethnicity affects cord blood transplant outcomes

A retrospective cohort study of 885 umbilical cord blood transplant (UCBT) recipients (612 whites, 145 blacks, and 128 Hispanics) has found that 2-year overall survival differed according to race/ethnicity: 44% for whites, 34% for blacks, and 46% for Hispanics (p=0.008). The study analyzed outcomes in patients with leukemia and myelodysplastic syndromes undergoing single-unit UCBT from 1995-2006 and reported to CIBMTR (Center for International Blood and Marrow Transplant Research). However, the study also found that when using well-matched cord blood units with higher cell doses, black patients and white patients had comparable survival.

Ballen KK, et al. Biol Blood Marrow Transplant »

Meta-analysis: ATG can reduce severe acute GVHD

A meta-analysis pooling results of 7 published randomized phase III controlled trials (total n=733) has found that antithymocyte globulin (ATG) can significantly reduce the incidence of grade III-IV acute GVHD. Patients receiving ATG had a combined a risk ratio (RR) of 0.51 when compared to patients not receiving ATG (p=0.03). However, ATG had no effect on rates of grade II acute GVHD (RR=0.79; p=0.35) or grade I acute GVHD (RR=1.42; p=0.28). ATG was also not associated with a significant reduction in the incidence of non-relapse mortality (RR=0.74; p=0.08).

Kumar A, et al. Leukemia »


CME: Management of Advanced Non-Hodgkin Lymphomas

Management of Advanced Non-Hodgkin Lymphomas four-part CME series reviews treatment options for follicular, mantle cell, diffuse large B-cell, and T-cell lymphomas. Learn about first- and second-line treatment options for relapsed/refractory patients, including novel agents, and both allogeneic and autologous transplantation.
Access NHL CME program »

Test Your Knowledge

When was the first successful unrelated transplant for leukemia?

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Other Noteworthy Articles
HCT for primary plasma cell leukemia

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Autologous SCT in follicular lymphoma

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Treatment of relapsed AML after reduced-intensity HCT

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Resources For You
Non-Hodgkin Lymphoma Resources

Access clinical resources, education and the latest research to help guide decision-making when considering transplant as a treatment for patients with non-Hodgkin lymphomas (NHL). Access resources »

Resources For Your Patients

Be The Match Patient Services has a new Facebook page where patients, caregivers and families can connect with each other before, during, or after transplant. Patients connect >>

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