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February 2012 View as a webpage | Forward to a colleague | Not subscribed? Subscribe here
Advances in Transplantation
Featured Articles

Updated screening guidelines for HCT recipients

This report from an international group of hematopoietic cell transplantation (HCT) experts updates the screening and preventive practices for HCT recipients that were first published in 2006. The guidelines apply to pediatric and adult recipients of autologous and allogeneic HCT, and establish tests and procedures appropriate at six months, one year, and annually thereafter, when many recipients have returned to the care of community health care providers. New in this update are a list of late complications requiring greater vigilance or alternate follow-up schedule, and recommended vaccinations for both autologous and allogeneic HCT recipients.

Majhail NS, et al. Biol Blood Marrow Transplant »

Navneet Majhail MD
Navneet Majhail, M.D.

Author Commentary

Commentary on new guidelines

Navneet Majhail, M.D., NMDP Medical Director, Health Services Research, provides additional insight on the above article.
Read commentary »

Selection of optimal graft sources

Three alternative graft choices are available to hematopoietic cell transplant (HCT) patients who cannot locate an HLA-matched related or unrelated donor: umbilical cord blood, a haploidentical donor, and a mismatched unrelated donor. This review evaluates the pros and cons of each graft source based on factors such as donor availability, rates of acute and chronic GVHD, hematologic recovery, immune reconstitution, rate of graft failure, and relapse.

Ballen KK, et al. Blood » 

Comparable outcomes after matched related, unrelated HCT

This study of 2,223 patients ≥21 years with acute myelogenous leukemia who underwent allogeneic HCT shows no significant differences in survival based on stem cell source (related or unrelated donor). This retrospective analysis of data reported to CIBMTR (Center for International Blood and Marrow Transplant Research) of transplants between 2002-2006 compared HCT outcomes using HLA-matched related (n=624), 8/8 matched unrelated (n=1,193), and 7/8 matched unrelated donors (n=406). A multivariate analysis revealed that matched related and 8/8 unrelated donor HCT recipients had similar survival (relative risk, 1.03; p=0.62).

Saber W, et al. Blood » 

High-resolution HLA matching improves transplant outcomes

This single-center study of pediatric patients transplanted for acute lymphoblastic leukemia (ALL) has found a significant increase in overall survival (OS) since the introduction of high-resolution HLA donor-patient matching at the center. Researchers at the Bristol Royal Hospital for Children analyzed 356 consecutive pediatric ALL transplants between 1988-2007 and found that high-resolution matching begun in 2002 correlated with a more than 25% improvement in 2- and 5-year OS (p=0.009, p=0.005, respectively). They also found that 2-year OS in transplants after 2002 was comparable between matched related and unrelated donor transplants: 80.8% vs. 78.8%; (p=n.s.).

Harvey J, et al. Bone Marrow Transplant » 


Access NMDP webinar of PBSC vs. marrow study results

View a recording of the PBSC vs. Marrow Study Results webinar discussing the initial results of the BMT CTN Protocol (0201) Phase III PBSC versus Marrow Study that were presented during the 2011 American Society of Hematology Annual Meeting.
Access the NMDP-sponsored webinar »

Test Your Knowledge

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Other Noteworthy Articles
Late effects after pediatric HCT

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NMDP symposium on HCT in 2020

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Transplanting patients with SCID

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Post-transplant AZA can lower GVHD rates

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Resources For You
Non-Hodgkin Lymphoma Resources

Access clinical resources, education and the latest research to help guide decision-making when considering transplant as a treatment for patients with non-Hodgkin lymphomas (NHL). Access resources »

Resources For Your Patients

Be The Match Patient Services has a new Facebook page where patients, caregivers and families can connect with each other before, during, or after transplant. Patients connect >>

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Access outcomes data slides, CME, clinical references, patient education and more.

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